1) Cellular immune response (Concentration of leukocyte populations (Monocyte / Granulocyte subpopulations [Proinflammatory markers], monocytes: (CD14 + / CD16-), (CD14 + / CD16 +/-), (CD16 + / CD16 +); granulocytes: (CD33 + / CD15 + / CD11b)). Measurement time: at baseline and, at weeks 9 and 17.
2) Functionality of the immune system (In leukocyte populations: Expression of leukocyte activation markers in monocytes and lymphocytes: (HLADR and CD38); Regulatory cell fraction analysis: (CD45 +, CD4 +, CD25 +, D127 low); Recent migrant cells of the Thymus: (CD45RA +, CD62L +, CD31 +); Circulating memory populations: (CD4 and CD8 +, CD28, CD57, D45RA, CR7 and CD62L)). Measurement time: at baseline and, at weeks 9 and 17.
3) Antigen-specific delayed hypersensitivity response (Tuberculin antigen (PPD); Candidine; Tetanus toxoid). Measurement time: at baseline and, at weeks 9 and 17.
4) General immunological response (Hematological response (Lymphocytes, Monocytes, Granulocytes, Platelets; Neutrophil / lymphocyte ratio (NLR), Platelet / lymphocyte ratio, NLR / Platelet ratio). Measurement time: at baseline and, at weeks 9 and 17.
5) Immunological (Humoral immune response). Quantification of Immunoglobulins and Complement (Quantification of Immunoglobulins: IgA, IgM, IgG; Components of the complement system: C3 and C4). Measurement time: at baseline and, at weeks 9 and 17.
6) Soluble markers of the inflammatory response. Quantification of the soluble markers of the inflammatory response (Acute phase reactants: Serum ferritin, C Reactive Protein). Measurement time: at baseline and, at weeks 9 and 17.
7) Infections (Frequency of infectious events (Number of infectious events recorded); Severity of the infectious event (Use of antibiotic treatment and the management of the patient according to their clinical severity, it will be classified as: outpatient, open room hospitalization, ICU (intensive care unit) hospitalization, ICU hospitalization with septic shock); Location of the infectious event (It will be classified as: infection of the vascular access: AVF (internal arterio-venous fistula), permanent catheter, transient catheter; infection in another specific organ (upper respiratory, lower respiratory (pneumonia, bronchopneumonia), genitourinary, digestive, CNS (central nervous system) or other; Systemic infection. If the result of the blood culture is positive and ICU admission occurs); Etiology of the infectious event (Type of causing germ: bacterial, viral, fungal, parasitic or other); Use of antibiotic treatment (Yes / No); Route of administration of the antibiotic to treat the infection (It will be classified as: systemic (oral, Intramuscular, subcutaneous, intravenous, other) or No (local)); Hospital admission time (Time between admission date and hospital discharge date)). Measurement time: Measurement time: at baseline and, at weeks 9 and 17.
8) Adverse clinical events-AE (They will be measured as: -Occurrence of AE (Yes, No), -Description of the AE (name of the event), -Intensity of the AE (mild, moderate, severe), -Relation of causality (no related, doubtful, possible, probable, definitive) -Measures taken (None, Administration of some pharmacological therapy, Addition of a non-pharmacological therapy, Exit of the study, Hospitalization / prolongation of hospitalization), -Result (Fully resolved, Solved with sequelae, Conditions in improvement, Present and unchanged condition, Worsening, Death caused by this event)). Measurement time: at baseline and, at weeks 9 and 17.