1.Shibuya K, Mathers CD, Boschi-Pinto C, Lopez AD, Murray CJ. Global and regional estimates of cancer mortality and incidence by site: II. Results for the global burden of disease 2000. BMC Cancer 2002;2:37. 2.Ferlay J, Autier P, Boniol M, et al. Estimates of the cancer incidence and mortality in Europe in 2006. Ann Oncol 2007;18:581–592. 3.Jemal A, Siegel R, Ward E, et al. Cancer statistics, 2007. CA Cancer J Clin 2007;57:43–66. 4.Kamangar F, Dores GM, Anderson WF. Patterns of cancer incidence, mortality, and prevalence across five continents: defining priorities to reduce cancer disparities in different geographic regions of the world. J Clin Oncol 2006;24:2137–2150. 5.Edwards BK, Brown ML, Wingo PA, et al. Annual report to the nation on the status of cancer, 1975–2002, featuring population-based trends in cancer treatment. J Natl Cancer Inst 2005;97:1407–1427. 6.American Cancer Society: Cancer Facts and Figures 2012. Atlanta, Ga: American Cancer Society, 2012. 7.Spitz MR, Fueger JJ, Goepfert H, Hong WK, Newell GR. Squamous cell carcinoma of the upper aerodigestive tract. A case comparison analysis. Cancer 1988;61:203–8. 8.Wynder EL, Stellman SD. Impact of long-term filter cigarette usage on lung and larynx cancer risk: a case-control study. J Natl Cancer Inst 1979;62:471–7. 9.Brennan JA, Boyle JO, Koch WM, et al. Association between cigarette smoking and mutation of the p53 gene in squamous-cell carcinoma of the head and neck. N Engl J Med 1995;332:712–7. 10.Gissmann L, Wolnik L, Ikenberg H, Koldovsky U, Schnurch HG, zur Hausen H. Human papillomavirus types 6 and 11 DNA sequences in genital and laryngeal papillomas and in some cervical cancers. Proc Natl Acad Sci USA 1983;80:560–3. 11.Mineta H, Ogino T, Amano HM, et al. Human papilloma virus (HPV) type 16 and 18 detected in head and neck squamous cell carcinoma. Anticancer Res 1998;18:4765–8. 12.Mork J, Lie AK, Glattre E, et al. Human papillomavirus infection as a risk factor for squamous-cell carcinoma of the head and neck. N Engl J Med 2001;344:1125–31. 13.Fahraeus R, Fu HL, Ernberg I, et al. Expression of Epstein-Barr virus-encoded proteins in nasopharyngeal carcinoma. Int J Cancer 1988;42:329–38. 14.Mendenhall WM, Werning JW, Pfister DG: Treatment of head and neck cancer. In: DeVita VT Jr, Lawrence TS, Rosenberg SA: Cancer: Principles and Practice of Oncology. 9th ed. Philadelphia, Pa: Lippincott Williams & Wilkins, 2011, pp 729-80. 15.Chen L, Gallicchio L, Boyd-Lindsley K, et al.: Alcohol consumption and the risk of nasopharyngeal carcinoma: a systematic review. Nutr Cancer 61 (1): 1-15, 2009. 16.Choi WH, Hu KS, Culliney B, et al.: Cancer of the oropharynx. In: Harrison LB, Sessions RB, Hong WK, eds.: Head and Neck Cancer: A Multidisciplinary Approach. 3rd ed. Philadelphia, PA: Lippincott, William & Wilkins, 2009, pp 285-335. 17.Oficina Nacional de Estadísticas e Información. Esperanza de vida. Cuba y provincias. 2005 - 2007. Cálculo por sexo y edades. La Habana. 2009. 18.Oficina Nacional de Estadísticas e Información. Anuario Estadístico de Cuba 2009, edición 2010. La Habana 2010. ISNN 0574-6132. 19.Cooper JS, Pajak TF, Forastiere AA, et al. Postoperative concurrent radiotherapy and chemotherapy for high-risk squamous-cell carcinoma of the head and neck. N Engl J Med 2004;350:1937–44. 20.Bernier J, Domenge C, Ozsahin M, et al. Postoperative irradiation with or without concomitant chemotherapy for locally advanced head and neck cancer. N Engl J Med 2004;350:1945–52. 21.Baujat B, Audry H, Bourhis J, et al.: Chemotherapy in locally advanced nasopharyngeal carcinoma: an individual patient data meta-analysis of eight randomized trials and 1753 patients. Int J Radiat Oncol Biol Phys 64 (1): 47-56, 2006. 22.Chen Y, Liu MZ, Liang SB, et al.: Preliminary results of a prospective randomized trial comparing concurrent chemoradiotherapy plus adjuvant chemotherapy with radiotherapy alone in patients with locoregionally advanced nasopharyngeal carcinoma in endemic regions of china. Int J Radiat Oncol Biol Phys 71 (5): 1356-64, 2008. 23.Lee AW, Tung SY, Chua DT, et al.: Randomized trial of radiotherapy plus concurrent-adjuvant chemotherapy vs radiotherapy alone for regionally advanced nasopharyngeal carcinoma. J Natl Cancer Inst 102 (15): 1188-98, 2010 24.Lee AW, Tung SY, Chan AT, et al.: A randomized trial on addition of concurrent-adjuvant chemotherapy and/or accelerated fractionation for locally-advanced nasopharyngeal carcinoma. Radiother Oncol 98 (1): 15-22, 2011. 25.Lee AW, Tung SY, Ngan RK, et al.: Factors contributing to the efficacy of concurrent-adjuvant chemotherapy for locoregionally advanced nasopharyngeal carcinoma: combined analyses of NPC-9901 and NPC-9902 Trials. Eur J Cancer 47 (5): 656-66, 2011. 26.Chen CY, Han F, Zhao C, et al.: Treatment results and late complications of 556 patients with locally advanced nasopharyngeal carcinoma treated with radiotherapy alone. Br J Radiol 82 (978): 452-8, 2009. 27.Chepeha DR, Haxer MJ, Lyden T: Rehabilitation after treatment of head and neck cancer. In: DeVita VT Jr, Lawrence TS, Rosenberg SA: Cancer: Principles and Practice of Oncology. 9th ed. Philadelphia, Pa: Lippincott Williams & Wilkins, 2011, pp 781-8. 28.Harrison LB, Sessions RB, Hong WK, eds.: Head and Neck Cancer: A Multidisciplinary Approach. 3rd ed. Philadelphia, PA: Lippincott, William & Wilkins, 2009. 29.Pignon JP, Bourhis J, Domenge C, Designe L. Chemotherapy added to locoregional treatment for head and neck squamous-cell carcinoma: three meta-analyses of updated individual data. MACH-NC Collaborative Group. Meta-Analysis of Chemotherapy on Head and Neck Cancer. Lancet 2000;355:949–55. 30.Bourhis J, Amand C, Pignon J-P. Update of MACH-NC (Meta- Analysis of Chemotherapy in Head & Neck Cancer) database focused on concomitant chemoradiotherapy. J Clin Oncol 2004; 22 [Abstract 5505]. 31.Forastiere AA, Metch B, Schuller DE, et al. Randomized comparison of cisplatin plus fluorouracil and carboplatin plus fluorouracil versus methotrexate in advanced squamous-cell carcinoma of the head and neck: a Southwest Oncology Group study. J Clin Oncol 1992;10:1245–51. 32.Clavel M, Vermorken JB, Cognetti F, et al. Randomized comparison of cisplatin, methotrexate, bleomycin and vincristine (CABO) versus cisplatin and 5-fluorouracil (CF) versus cisplatin (C) in recurrent or metastatic squamous cell carcinoma of the head and neck. A phase III study of the EORTC Head and Neck Cancer Cooperative Group. Ann Oncol 1994;5:521–6. 33.De Andres L, Brunet J, Lopez-Pousa A, et al. Randomized trial of neoadjuvant cisplatin and fluorouracil versus carboplatin and fluorouracil in patients with stage IV-M0 head and neck cancer. J Clin Oncol 1995;13:1493–500. 34.Jacobs C, Lyman G, Velez-Garcia E, et al. A phase III randomized study comparing cisplatin and fluorouracil as single agents and in combination for advanced squamous cell carcinoma of the head and neck. J Clin Oncol 1992;10:257–63. 35.Adamo V, Ferraro G, Pergolizzi S, et al. Paclitaxel and cisplatin in patients with recurrent and metastatic head and neck squamous cell carcinoma. Oral Oncol 2004;40:525–31. 36.Specht L, Larsen SK, Hansen HS. Phase II study of docetaxel and cisplatin in patients with recurrent or disseminated squamous-cell carcinoma of the head and neck. Ann Oncol 2000;11:845–9. 37.Bernier J, Domenge Ch, Ozsahin M, Matuszewska K, Lefèbvre JL, Greiner RH, et al, for the European Organization for Research and Treatment of Cancer Trial 22931. Postoperative Irradiation with or without Concomitant Chemotherapy for Locally Advanced Head and Neck Cancer. N Engl J Med 2004; 350:1945-1952, May 6, 2004. 38.Williams C , Collingwood M , Simera I , Grafton C . Short versus long duration infusions of paclitaxel for any advanced adenocarcinoma. Cochrane Database of Systematic Reviews 2002, Issue 3. Art. No.: CD003911. DOI: 10.1002/14651858.CD003911. 39.Gibson MK, Li Y, Murphy B, et al. Randomized phase III evaluation of cisplatin plus fluorouracil versus cisplatin plus paclitaxel in advanced head and neck cancer (E1395): An Intergroup Trial of the Eastern Cooperative Oncology Group. J Clin Oncol 2005;23(15):3562-3567. 40.FDA Approves New Treatment for Advanced Head and Neck Cancer. October 18, 2006. 41.Vermorken JB, Remenar E, Van Herpen C, et al. Standard cisplatin/infusional 5-fluorouracil vs docetaxel plus PF as neoadjuvant chemotherapy for nonresectable locally advanced squamous cell carcinoma of the head and neck: A phase III trial of the EORTC Head and Neck Cancer Group. J Clin Oncol 2004 Proc Amer Soc Clin Oncol;22(14S)[Abstr. 5508]. 42.Vermorken JB, Remenar E, van Herpen C, Gorlia Th, Mesia R, Degardin M, et al, for the EORTC 24971/TAX 323 Study Group. Cisplatin, Fluorouracil, and Docetaxel in Unresectable Head and Neck Cancer. N Eng J Med 2007 Oct 25: 357(17):1695-1704. 43.Posner MR, Hershock DM, Blajman CR, Mickiewicz E, Winquist E, Gorbounova V, et al, for the TAX 324 Study Group. Cisplatin and Fluorouracil Alone or with Docetaxel in Head and Neck Cancer. N Eng J Med 2007 Oct 25: 357(17):1705-1715. Forastiere AA, Metch B, Schuller DE, et al. Randomized comparison of cisplatin plus flurouracil and carboplatin plus fluorouracil versus methotrexate in advanced squamous cell carcinoma of the head and neck: A Southwest Oncology Group Study. J Clin Oncol 1992;10(8):1245-1251. 44.Schrijvers D, Van Herpen C, Kerger J, et al. Docetaxel, cisplatin and 5-fluorouracil in patients with locally advanced unresectable head and neck cancer: a phase I-II feasibility study. Annals of Oncology 2004;15:638-645. 45.Schuchter LM, Hensley ML, Meropol NJ, Winer EP; American Society of Clinical Oncology Chemotherapy and Radiotherapy Expert Panel. 2002 update of recommendations for the use of chemotherapy and radiotherapy protectants: clinical practice guidelines of the American Society of Clinical Oncology. J Clin Oncol. 2002 Jun 15;20(12):2895-903. 46.Bonner JA, Harari PM, Giralt J, et al. Radiotherapy plus cetuximab for squamous-cell carcinoma of the head and neck. N Engl J Med. 2006;354:567-578. 47.Vermorken J, Bourhis J, Trigo J, et al. Cetuximab (Erbitux®) in recurrent/metastatic (R&M) squamous cell carcinoma of the head and neck (SCCHN) refractory to first-line platinum-based therapies. Proc Am Soc Clin Oncol. 2005;23:501s. Abstract 5505. 48.Trigo R, Hitt R, Koralewski P, et al. Cetuximab monotherapy is active in patients (pts) with platinum-refractory recurrent/metastatic squamous cell carcinoma of the head and neck (SCCHN): Results of a phase II study. Proc Am Soc Clin Oncol. 2004;23:487. Abstract 5502. 49.Herbst RS, Arquette M, Shin DM, et al. Phase II multicenter study of the epidermal growth factor receptor antibody cetuximab and cisplatin for recurrent and refractory squamous cell carcinoma of the head and neck. J Clin Oncol. 2005;23:5578-5587. 50.Merlano MC, Numico G, Russi EG, et al. Cetuximab (C-Mab) and chemo-radiation (CT-RT) for loco-regional advanced squamous cell carcinoma of the head and neck (HNC): a phase II study. Proc Am Soc Clin Oncol. 2007;25:309s. Abstract 6043. 51.Vermorken J, Mesia R, Vega V, et al. Cetuximab extends survival of patients with recurrent or metastatic SCCHN when added to first line platinum based therapy - Results of a randomized phase III (Extreme) study. Proc Am Soc Clin Oncol. 2007;25. Abstract 6091. 52.Burtness B, Goldwasser MA, Flood W, et al. Phase III randomized trial of cisplatin plus placebo compared with cisplatin plus cetuximab in metastatic/recurrent head and neck cancer: an Eastern Cooperative Oncology Group study. J Clin Oncol. 2005;23:8646-8654. 53.Hitt R, Irigoyen A, Nunez J, et al. Phase II study of combination cetuximab and weekly paclitaxel in patients with metastatic/recurrent squamous cell carcinoma of head and neck (SCCHN): Spanish Head and Neck Cancer Group (TTCC). Proc Am Soc Clin Oncol. 2007;25:302s. Abstract 6012. 54.Bourhis J, Overgaard J, Audry H, Ang KK, Saunders M, Bernier J, et al, on behalf of the Meta-Analysis of Radiotherapy in Carcinomas of Head and neck (MARCH) Collaborative Group. Hyperfractionated or accelerated radiotherapy in head and neck cancer: a meta-analysis. Lancet 2006; 368. 55.Budach W, Hehr T, Budach V, C Belka and Dietz K. A meta-analysis of hyperfractionated and accelerated radiotherapy and combined chemotherapy and radiotherapy regimens in unresected locally advanced squamous cell carcinoma of the head and neck. BMC Cancer 2006 Jan 31;6:28. 56.Califano J, van der Riet P, Westra W, et al. Genetic progression model for head and neck cancer: implications for field cancerization. Cancer Res 1996;56:2488–92. 57.Huang Q, Yu GP, McCormick SA, et al. Genetic differences detected by comparative genomic hybridization in head and neck squamous cell carcinomas from different tumor sites: construction of oncogenetic trees for tumor progression. Genes Chromosomes Cancer 2002;34:224–33. 58.Jeon GA, Lee JS, Patel V, et al. Global gene expression profiles of human head and neck squamous carcinoma cell lines. Int J Cancer 2004;112:249–58. 59.Chen YJ, Lin SC, Kao T, et al. Genome-wide profiling of oral squamous cell carcinoma. J Pathol 2004;204:326–32. Viloria-Petit A, Crombet T, Jothy S. et al. Acquired resistance to the antitumor effect of epidermal growth factor receptor-blocking antibodies in vivo: a role for altered tumor angiogenesis. Cancer Res. 2001; 61(13):5090-5101. 60.Crombet-Ramos T, Rak J, Perez R, & Viloria-Petit A. Anti-proliferative, anti-angiogenic and proapoptotic activity of h-R3: A Humanized anti-EGFR antibody. Int. J. Cancer 2002; 101: 567-575. 61.Pérez R, Betsholtz C, Westermark B. Frequent expression of growth factors for messenquimal cells in human mamary carcinoma cell lines. Cancer Research 1987; 47, 3425-3429. 62.Dobashi Y., Stren DF., Membrane anchored form of EGF stimulate focus formation and intercellular comunication. Oncogene. 1991; 6:1151-1159. 63.Solano ME, Perera A, Torres O, Iznaga N, Torres F, Perez R, Lage A. Pharmacological evaluation of humanized anti-epidermal growth factor receptor, monoclonal antibody h-R3, in patients with advanced epithelial-derived cancer. J Immunother. 2003 Mar-Apr; 26(2):139-48. 64.Crombet T, Osorio M, Cruz T, Roca C, del Castillo R, Iznaga-Escobar N, et al. Use of the Humanized Anti-Epidermal Growth Factor Receptor Monoclonal Antibody h-R3 in Combination With Radiotherapy in the Treatment of Locally Advanced Head and Neck Cancer Patients, Journal of Clinical Oncology 2004, May 1;22(9).. 65.Crombet T, Osorio M, Cruz T, Roca C, del Castillo R, Mon R, et al. Use of the Humanized Anti-Epidermal Growth Factor Receptor Monoclonal Antibody h-R3 in Combination With Radiotherapy in the Treatment of Locally Advanced Head and Neck Cancer Patients. J Clin Oncol. 2004;22:1646-1654. 66.Rodríguez MO, Rivero TC, Bahi RD, Muchuli CR, Bilbao MA, Vinageras EN, et al. Nimotuzumab plus radiotherapy for unresectable squamous-cell carcinoma of the head and neck. Cancer Biology & Therapy. 2010;9(5):343-349. 67.Clinical Study Report Protocol Number YMB1000/004 “An Open Phase I Dose Escalation Study to Assess the Safety of TheraCIM-hR3 (Ymb1000), (h-R3) in Conjunction with Radiotherapy in Patients with Advanced (Unresectable) Squamous Cell Carcinoma of the Head and Neck Who are Suitable for Radiotherapy”. June 27, 2007. 68.HUANG XD, XU GZ, GAO L, YI JL, LU TA, WU SX, et al. Multi-center Phase ? Clinical Trial of h-R3, the Recombined Humanized Anti-Epidermal Factor Receptor Monoclonal Antibody, in Combination with Radiotherapy in Patients with Locoregionally Advanced Nasopharyngeal Carcinoma Chin J 0ncol, March 2007, 29 (3): 197-201. 69.Ramakrishnan MS, Eswaraiah A, Crombet-Ramos T, Piedra P, y cols. Nimotuzumab, a promising therapeutic monoclonal antibody for treatment of tumors of epithelial origin. [mAbs 1:1, 41-48; January/February 2009]; ©2009 Landes Bioscience. 70.Reddy B. K., et al Clinigene International Pvt Ltd. BIOMAb EGFRTM (Nimotuzumab/h-r3) in Combination With Standard of Care in Squamous Cell Carcinoma of Head and Neck (SCCHN). I. J. Radiation Oncology Biology Physics Volume 69, Number 3, Supplement, 2007. 71.Reddy B.K et al.”A phase IIb 4-arm open label randomized study to asses the safety and efficacy of h-R3 monoclonal antibody against EGFR in combination with chemoradiation therapy or radiation therapy in patients with advanced (stage III or IVA) inoperable head and neck cancer”. Poster presented at the American Society of Clinical Oncology (ASCO) Annual Meeting, Poster No. C02/Abstract No. 12504 ( 2009). 72.Krishnamurthyreddy B., et all, "A phase IIb 4 arm open label randomized study to assess the safety and efficacy of hR3 monoclonal antibody against EGFR in combination with chemoradiation therapy or radiation therapy in patients with advanced (stage III or IVA) inoperable head and neck cancer. ASCO 2009, ABst 6041. 73.Special Access Program with Nimotuzumab in advanced H&N patients. 74.Follow up for 18 months on treatment. IV Nimotuzumab Global Meeting, Varadero, November 2008. 75.León X, Hitt R, Constenla M, et al. A retrospective analysis of the outcome of patients with recurrent or metastatic squamous cell carcinoma of the head and neck who are progressing while on a platinum-based palliative chemotherapy. Proc Am Soc Clin Oncol 2003; 22: 502. 76.Herbst RS, Arquette M, Shin DM, et al. Epidermal growth factor receptor antibody cetuximab for recurrent and refractory squamous cell carcinoma of the head and neck: a phase II, multicentre study. J Clin Oncol 2005; 23: 5578-87. Baselga J, Trigo JM, Bourhis J, et al. A phase II multicenter study of the anti-epidermal growth factor receptor (EGFR) monoclonal antibody cetuximab in combination with platinum-based chemotherapy in patients with refractory metastatic and/or recurrent squamous cell carcinoma of the head and neck (SCCHN). J Clin Oncol 2005; 23: 5568-77. 77.Trigo JM, Hitt R, Koralewski P, et al. Cetuximab monotherapy is active in patients with platinum-refractory recurrent/metastatic squamous cell carcinoma of the head and neck. Proc Am Soc Clin Oncol 2004; 23: 488s. 78.Clinical Study Report Phase II Study on the Efficacy of OSAG 101 (Theraloc®) in Relapses of High Grade Gliomas in Juvenile Patients. Feb 3, 2006. 79.Tania Crombet Ramos, Javier Figueredo, Mauricio Catala, Sandra González, Julio C. Selva, Tania M. Cruz, et al. Treatment of High-Grade Glioma Patients with the Humanized Anti-Epidermal Growth Factor Receptor (EGFR) Antibody h-R3 Report from a Phase I/II Trial Cancer Biology & Therapy 5:4, 375-379, April 2006. 80.Berdasco A. Evaluación del estado nutricional del adulto mediante la antropometría. Revista Cubana Aliment Nutr 2002; 16(2): 146-52
