1. Nutritional status (Body Max Index calculated by Weight/(Height*Height), the weight expressed in Kg and, the height expressed in meters). Measurement time: at baseline, in every CT cycle and, 3 weeks after the third CT cycle. 2. Compliance with the planned chemotherapy schedule (Yes, No).Measurement time: at baseline, in every CT cycle and, 3 weeks after the third CT cycle. Safety variables 3. Adverse Events- AE. Measurement time: in every CT cycle and, 3 weeks after the third CT cycle. It will measure by: - Occurrence of some AE in the subject (Yes, No). -Type of AE (Description of AE using the Common Terminology Criteria for Adverse Events (CTCAE)-version 4.0) - Intensity of the AE: (Light, Moderate, Severe, Serious that threatens life or incapacitates the subject , Death). - Gravity of the AE (Serious, Not serious) - Duration of the AE (Difference of dates between the start and end of the event) - Attitude regarding the treatment under study (No changes, Dose modification, temporary interruption of the study treatment, Definitive interruption of the study treatment) - Result of the AE (Recovered, Improved, Persisted, Squeals) - Causality relationship (Very probable, Probable, Possible, Improbable, Unrelated, Not evaluable). 4. Laboratory tests (Hemoglobin-g/L, Hematocrit-%, Erythrocyte-109/l, Platelets-109/l, Leukocytes 109/l, Glycemia- mmol/l, Cholesterol-mmol/l, Triglycerides-mmol, Uric acid- µmol/l, Creatinine-mmol/l, Total and direct bilirubin-in μmol/l, Alkaline Phosphatase-U/L, ALT-U/L , AST-U/L, Total proteins- g/l, Albumin-g/l). Measurement time: at baseline, before second and third CT cycle and, 3 weeks after the third CT cycle.