Section to complete information about the inclusion and exclusion criteria for participant selection, including age and gender.
Inclusion criteria:
1) Apparently healthy subjects, both sexes. 2) Age from 18 up to 65 years old. 3) Current contraceptive device use for women on reproductive age or not planning a pregnancy in the forthcoming six month after enrollment in the trial. 4) Signing of the written inform consent act.
Exclusion criteria:
1) History of viral hepatitis type B or previous vaccination against Hepatitis B. 2) Seropositivity for HBsAg (HBsAg+) 3) Underlying immunosuppressive disease, current intake of immunosuppressor drugs (including steroids) in the six month period prior to study entry. 4) Non-controlled Chronic diseases (eg. Arterial hypertension, Diabetes mellitus, renal failure, heart failure, hyper-thiroidism, malignant neoplasia, epilepsy, etc), autoimmune disease (Systemic lupus erithematosus, rheumatoid arthritis, Multiple sclerosis, Type 1 Diabetes Mellitus, etc.) 5) Feverish states (>37.5°C) at the moment of each vaccination visit 6) History of severe allergy (Asthma Grade III or IV, urtycaria, Dermatitis, Bronchitis, etc.). 7) History of thiomersal allergy or allergy to any component of the vaccine. 8) Pregnancy or breastfeeding.