1- Written informed consent. 2- Aged between 18-50 years. 3- Volunteers of both sexes. 4- Volunteers’ weight: +/- 15% of their ideal weight for height. 5- Failure to submit evidence of organic or psychiatric disease according to interrogation, physical examination and laboratory tests. 6- Not have evidence or history of diseases such as bronchial asthma, hypertension, bad-absorption syndrome, peptic ulcer or duodenal present, liver failure, kidney failure, severe allergic reactions, atopic dermatitis, cardiovascular disorders, diabetes mellitus. 7- Satisfactory physical examination. 8- Present vital signs values within the following reference ranges. Systolic blood pressure between 90 and 130 mm Hg and diastolic blood pressure between 60 and 80 mm Hg, heart rate between 60 to 100 beats per minute, respiratory rate between 12 to 20 breaths per minute. 9- Not having consumed alcohol, drinks containing xanthines (tea, coffee, and cola) and carbonated beverages three days before the start of each period and during it. 10- Smoking or non-smoking subjects. A record of cigars use will be made. 11- Laboratory results within the acceptance range. For some parameters such as blood counts with differential, urine, etc., a result found outside the reference range will be carefully evaluated by the clinical investigator. 12- Post-menopausal women (age 45 or older with at least two years of amenorrhea) or documented history of hysterectomy and / or oophorectomy double sex. 13- Female subject within childbearing age who use a (non-hormonal) contraceptive effective method at least 14 days before the first dose of product research and continued throughout the study. The decision to use effective contraception will be conducted by the principal investigator or clinical investigator responsible of medical care.