Patients treated at home: Group I (experimental 1): Nebulization with Homeostec (5 ml) + Paracetamol (500 mg). The patient will receive a bottle with 5 ml of Homeostec (electrolysed solution with neutral pH), which will be placed in the nebulizer container. The patient will receive sprays for 15 min, four times a day for 7 days. In addition, you can take Paracetamol 500 mg (orally) every 6 hours.Other medications may be added at the discretion of the treating physician as deemed necessary for the patient. Group II (experimental 2): Nebulization with Homeostec (5 ml) + Paracetamol (500 mg) + Homeostec intravenously (15 ml, with dose escalation). The patient will receive a bottle with 5 ml of Homeostec (neutral pH electrolyzed solution), which will be placed in the nebulizer container. The patient will receive sprays for 15 min, four times a day for 7 days. Additionally, 15 ml of Homeostec will be administered intravenously loaded in a 20 ml syringe. The solution will be applied to an arm vein using a butterfly-type IV application catheter connected to the syringe, in a period of 1 to 2 min, once every 24 hours for 7 days, by research personnel who will visit the patient in his home. The initial intravenous dose of 15ml per day will have successive increments, before reaching dose-limiting toxicity, or until a dose was found that prevented disease progression. In addition, you can take Paracetamol 500 mg (orally) every 6 hours. Other medications may be added at the discretion of the treating physician as deemed necessary for the patient. Group III (control 1, usual medical care): Paracetamol (500 mg). The patient will receive Paracetamol 500 mg (orally) every 6 hours. Other medications may be added at the discretion of the treating physician as deemed necessary for the patient. For group I and II: If there is nausea, vomiting and / or diarrhea, 30 ml of oral Homeostec is added, 4 times a day, for as long as symptoms lasted, plus 2 more days after symptoms disappeared. In patients with oropharyngeal ulcerations (causing intense throat pain), the indication is to gargle with 10 ml of Homeostec, 6 times a day, and swallow the solution after gargling with it. This is done for the number of days necessary for the pain to decrease Hospitalized patients (Includes patients on a regular floor or intensive care unit, with or without mechanical ventilation): Group IV (experimental 3): Homeostec (15 ml, with dose escalation) + Paracetamol (500 mg). The patient will receive 15 ml of Homeostec (pH neutral electrolyzed solution) intravenously loaded into a 20 ml syringe. The solution will be applied via a butterfly-type IV application catheter connected to the syringe, within 1 to 2 min once every 12 hours for 7 days. In addition, you can take Paracetamol 500 mg (orally) every 6 hours. Other medications may be added at the discretion of the treating physician as deemed necessary for the patient. Group V (control 2): 0.9% physiological solution (15 ml) + Paracetamol (500 mg). The patient will receive 15 ml of 0.9% Physiological Solution intravenously loaded into a 20 ml syringe. The solution will be applied via a butterfly-type IV application catheter connected to the syringe, within 1 to 2 min once every 12 hours for 7 days. In addition, you will receive paracetamol 500 mg (orally) every 6 hours. Other medications may be added at the discretion of the treating physician as deemed necessary for the patient.