Safety: 1. Occurrence of any Adverse event- AE (yes / no). Measurement time: 6 months. 2. AE description (Name of the adverse event). Measurement time: 6 months. 3. Duration of the AE (Difference between the start and stop date of the event). Measurement time: 6 months. 4. Intensity of AE (1. Light, 2. Moderate 3. Severe, 5. Very severe 5. Death, according to Common Toxicity Criteria (CTCAE) version 5.0). Measurement time: 6 months. 5. Gravity (Seriousness) of AE (Critical event / No serious. Serious event (seriously) be considered as causing the death of the patient, life-threatening, results in hospitalization or prolongation of existing hospitalization, causes disability / persistent or significant disability, birth defects or congenital anomalies or an important medical event that according to medical judgment, could endanger the health of the patient or may require medical or surgical intervention to prevent the occurrence of any of the previously listed outcomes). Measurement time: 6 months. 6. Causality relationship (1. Definitive, 2.Very probable, 3. Probable, 4. Possible, 5. Unlikely, 6. unrelated, 7. Unknown). Measurement time: 6 months. 7. Attitude towards drug (1. No change 2. Dose reduction 3. Temporary discontinuation of treatment. 4. Definitive Treatment discontinuation). Measurement time: 6 months. 8. Outcome of the event (1. reversible effect, 2. Effect 3. Death 4. Irreversible loss of patient monitoring). Measurement time: 6 months. Effect: Specific variables for the stratum of patients with cardiovascular sequelae. 9. Response to treatment (Favorable / Unfavorable. A favorable response to treatment will be considered when the patient progresses from greater to less cardiovascular damage according to the evaluative exercise stress test and according to the NYHA (New York Heart Association) classification. Unfavorable response: when, based on the above criteria, the patient progresses the greater the cardiovascular damage or the condition is not modified compared to the initial one). Measurement time: day 0 and month 1, month 3 and month 6. 10. Alterations in the parietal thickness of ventricular walls (Yes / No. It is the increase in the dimensions of the heart muscle, expressed in mm. It will be considered normal from 8 to 11 mm or abnormal: if increased, equal to or greater than 12 mm). Measurement time: day 0 and month 1, month 3 and month 6. 11. Pulmonary hypertension (Yes / No. Calculation of the mean pressure of the pulmonary artery. Normal pulmonary pressure <35 mmHg or pulmonary hypertension ≥ 35 mmHg will be considered). Measurement time: day 0 and month 1, month 3 and month 6. 12. Presence of intracardiac masses (Yes / No. Echocardiographic evidence of infrequent entities in the heart. If so, define: Thrombi, Tumors, Cysts, Vegetations, or others). Measurement time: day 0 and month 1, month 3 and month 6. 13. Alterations in the volume of cavities (Yes / No. Increase in the volumes of the different cardiac chambers expressed in ml. It will be classified into normal volumes or augmented volumes). Measurement time: day 0 and month 1, month 3 and month 6. 14. Valvular alterations (Yes / No. Modifications of the function and structure of the valve apparatus (mitral, tricuspid or pulmonary). If so, it is classified as: aortic, stenosis or insufficiency). Measurement time: day 0 and month 1, month 3 and month 6. 15. Alterations in left ventricular ejection fraction-LVEF (Yes / No. It is the fraction of the blood volume of the left ventricle expelled in systole (stroke volume) in relation to the volume of blood in it at the end of the diastole. If so, it is classified as: mild dysfunction: LVEF 46% to 55%, moderate dysfunction: LVEF 36% to 45%, severe dysfunction: LVEF less than or equal to 35% or, normal: LVEF greater than 55%). Measurement time: day 0 and month 1, month 3 and month 6. 16. Segmental contractibility (Yes / No. It is the contractile capacity of the heart by segments (mitral, tricuspid or pulmonary) determined by tissue Doppler (TDI). In case of abnormality, it is classified as: hypokinesia, akinesia or, normokinesia). Measurement time: day 0 and month 1, month 3 and month 6. 17. Presence of functional disorders (Yes / No. Determination of functional disorders due to systolic or diastolic dysfunction or both, structural due to anatomical alterations of the wall, partitions and valves, and mixed with a combination of the previous two. They are classified into functional disorders, structural disorders, or mixed disorders). Measurement time: day 0 and month 1, month 3 and month 6. Specific variables for the stratum of patients with renal sequelae. 18. Response to treatment (Favorable / Unfavorable, measured through the KDIGO functional classification of kidney damage. Favorable response to treatment will be considered: those patients who achieve clinical improvement given by moving from a category from higher to lower kidney damage. Unfavorable response: Patients who do not change category or go to a higher category at the end of the study). Measurement time: day 0 and month 1, month 3 and month 6. 19. Abnormal serum creatinine (the normal value is 0.7 to 1.3 mg / dL (61.9 to 114.9 µmol / L) for men and 0.6 to 1.1 mg / dL (53 to 97.2 µmol / L) for women). Measurement time: day 0 and month 1, month 3 and month 6. 20. Creatinine clearance (It is the test of renal function based on the rate of excretion by the kidneys of endogenous creatinine produced metabolically. Its reference value: 60 to 140 ml / min / 1.73m2SC. It will be measured from the Cockcroft-Gault formula based on serum creatinine). Measurement time: day 0 and month 1, month 3 and month 6. 21. Proteinuria (Measures the presence of protein in a random urine sample, normal values are 0 to 14 mg/dL). Measurement time: day 0 and month 1, month 3 and month 6. 22. Microalbuminuria (Measures the presence of albumin in the urine. Their reference values: 300 µg / mg or 30-300 mg/g). Measurement time: day 0 and month 1, month 3 and month 6. 23. Kidney size (in mm. It will be classified as: Normal (100 to 120 x 40 to 60), increased, or decreased with respect to the initial value). Measurement time: day 0 and month 1, month 3 and month 6. 24. Renal parenchyma (thickness in mm. In sagittal section on the internal contour. It will be classified as: normal (10 to 12 mm), increased or decreased, with respect to the initial value). Measurement time: day 0 and month 1, month 3 and month 6. 25. Echogenicity (It will be classified as: normal (10 to 12 mm), increased or decreased from the initial value). Measurement time: day 0 and month 1, month 3 and month 6. 26. Ecotexture (Homogeneous or heterogeneous). Measurement time: day 0 and month 1, month 3 and month 6. 27. Sine-parenchyma relationship (It will be classified as: normal (10 to 12), increased or decreased with respect to the initial value). Measurement time: day 0 and month 1, month 3 and month 6. 28. Presence of focal lesion (Yes / No). Measurement time: day 0 and month 1, month 3 and month 6. 29. Number of injuries (A total number of injuries). Measurement time: day 0 and month 1, month 3 and month 6. 30. Location (Localization of the injuries). Measurement time: day 0 and month 1, month 3 and month 6. 31. Extension of the lesion (for each one, in mm). Measurement time: day 0 and month 1, month 3 and month 6. 32. Other possible alterations (Yes / No. Dilation of the excretory system, alterations in the location, presence of lithiasis or congenital malformation). Measurement time: day 0 and month 1, month 3 and month 6. Specific variables for the stratum of patients with mixed sequelae. 33. Response to treatment if respiratory disorder (Measured through forced vital capacity: (favorable / unfavorable). Will be consider favorable response when the forced vital capacity (FVC) does not vary or is reduced by less than 10% in patients with pulmonary fibrosis and does not vary or is reduced by less than 5% in patients with another respiratory disorder with respect to the initial measurement. Unfavorable response: when the FVC is reduced more than 10% with respect to the initial measurement in patients with pulmonary fibrosis, and more than 5% in patients with another respiratory disorder). Measurement time: on day 63 (post induction) and 182. 34. Forced vital capacity-FVC (Which is the maximum amount of air that a person can expel into the lungs after a maximum inhalation, value observed in ml). Measurement time: on days 0, 63 and 182. 35. Maximum expiratory volume-VEM (It is the fraction of the forced vital capacity that can expire in the first second in a forced expiration after a maximum inspiration, observed value in ml). Measurement time: on days 0, 63 and 182. 36. Number of lesions (number of lesions that the patient presents at each moment of evaluation, measured by CT). Measurement time: on days 0, 63 and 182. 37. Type of lesion (nonspecific pulmonary fibrosis, tarnished virio pattern, reticulo-nodular pattern, or other). Measurement time: on days 0, 63 and 182. 38. Lesion location (In the right lung (Upper lobe: anterior, posterior or apical, Middle lobe: medial or lateral, or Lower lobe: apical, anterior, posterior, internal, external). In the left lung (Upper lobe: apical posterior, anterior, superior lingular, inferior lingular, Lower lobe: apical, anterior, posterior, external)). Measurement time: on days 0, 63 and 182. 39. Extension of the lesion (Area of the lesion in cm2). Measurement time: on days 0, 63 and 182. 40. Modification of the measurable lesion according to extension (increase, no variation or reduction). Measurement time: on days 0, 63 and 182. 41. Number of affected segments for non-measurable lesions (Number of affected segments). Measurement time: on days 0, 63 and 182. 42. Variation of the non-measurable lesion (increase, no variation or reduction). Measurement time: on days 0, 63 and 182. 43. Anti-RBD antibody titers (The antibody titers in response to vaccination will be determined in each patient). Measurement time: on days 0, 63 and 182. 44. Neutrophil/lymphocyte ratio (The neutrophil / lymphocyte ratio will be determined from the blood count values). Measurement time: on days 0, 63 and 182. 45. Platelet/lymphocyte ratio (The platelet / lymphocyte ratio will be determined from the values of the blood count). Measurement time: on days 0, 63 and 182. 46. Absolute count of CD4 + T cells (The amount and percentage of CD4 + T cells in the blood will be determined). Measurement time: on days 0, 63 and 182. 47. Absolute count of CD8 + T cells (The amount and percentage of CD8 + T cells in the blood will be determined). Measurement time: on days 0, 63 and 182. 48. Absolute count of CD28+ T cells (The percentage of CD8 + CD208- T cells in the blood will be determined). Measurement time: on days 0, 63 and 182. 49. CD4 / CD8 index (The CD4 / CD8 index in blood will be determined). Measurement time: on days 0, 63 and 182.