1) Reduction in the deterioration of lung function (Proportion of patients who did not require an increase in FiO2 to keep SO2 stable and without the need for intubation and / or Percentage of patients who decreased positive pressure values at the end of expiration [PEEP] ). Measurement time: On the 7th day after starting the treatment.
2) Need and time (in days) of non-invasive mechanical ventilation and/or oxygen therapy. Measurement time: During the stay in the COVID-19 internment area.
3) Measurement of hyperinflammation score parameters (temperature, visceromegaly, cytopenias, triglycerides, aspartate aminotransferase - TGO, fibrinogen, ferritin, D-dimer). Measurement time: at the beginning, at 72 hours and on the 7th day after starting the treatment.
4) Stay (days) in the COVID-19 internment area and global hospita (Time from the inclusion in the trial, in the COVID-19 internment area, until discharge from said area, as well as the global time of stay in the hospital (from admission to discharge)). Measurement time: during the stay in the COVID-19 internment area and hospital in general.
5) Sequential organ failure evaluation (SOFA score). Measurement time: daily, during the stay in the COVID-19 internment area.
6) Immunological evaluation through the determination of pro and anti-inflammatory cytokines and chemokines (IL-2, IL-4, IL-6, IL-10, IL-17, TNF, IFN alpha, IFN gamma, CXCL8, CCL5, CXCL9 , CCL2, CXCL10) through multiple bead-based immunoassays, with quantification of Th1, Th2 and TH17 type cytokines, chemokines and IFN alpha in human serum. Measurement time: at the beginning, at 72 hours and on the 7th day after starting the treatment.
8) Behavior of biomarkers: absolute lymphocyte count, C-reactive protein, erythrocyte sedimentation rate, lactate dehydrogenase - LDH, etc. Measurement time: at the beginning, 72 hours and 7th day after the start of treatment.
9) Antibody titers: IgM and IgG antibody titers against the S protein of the SARS-CoV-2 virus will be measured by ELISA. Measurement time: at the beginning, at 72 hours and on the 7th day after starting the treatment.
10) Cellular immunophenotype: It will be carried out through the analysis of cell populations by flow cytometry and confocal microscopy, using the markers: CD11c, MHC-II and BDCA-3, MDC-8, CD86, CD40, PDL-1, INF- α, TNF-α PD-1 and PD-L1, CTLA- and TIM-3 and IDO, CD103, CD69, CD44, CD62L CD3, CD4, CD8, INF-γ and granzyme B. Measurement time: at baseline, at 72 hours and on the 7th day after starting the treatment.
11) Imaging response: the evolution of pulmonary lesions will be evaluated by chest radiography, CT or pulmonary ultrasound. Measurement time: at the beginning, at 72 hours and on the 7th day after starting the treatment (and when clinically indicated).
12) Clinical Adverse Events-AE (They will be measured as: -Occurrence of AE (Yes, No), -Description of AE (name of event), -Intensity of AE (mild, moderate, severe), -Causality relationship (no related, doubtful, possible, probable, definitive), -Measures adopted (None, Administration of any pharmacological therapy, Addition of a non-pharmacological therapy, Study exit, Hospitalization / prolongation of hospitalization), -Result (Completely resolved, Resolved with sequelae, Conditions improving, Condition present and unchanged, Worsening, Death caused by this event)). Measurement time: daily during the entire period of admission to the COVID-19 internment area.