Section to complete information about primary and secondary outcomes including. It includes the metric or method of measurement used and, the time point for every outcome.
Primary outcome(s):
Real-time polymerase chain reaction test-TR-PCR (Positive/Negative). Measurement time: day 0, day 6, day 11
Clinical signs (fever, pain head, fatigue, sore throat, dry cough, dyspnea. Every signs evaluted like Yes/No). Measurement time: day 0 to day 11, day 15
Progression of clinical signs (equal, better, worse). Measurement time : day 0 to day 11, day 15
Key secondary outcomes:
C-reactive protein (values at mg/L). Measurement time: day 0, day 6, day 11
Serum ferritin (values at ug/L). Measurement time: day 0, day 6, day 11
Redox balance indicators (MDA (values at mmol/L). Total hydroperoxides (values at mmol/L). Nitric oxide (values at µmol/L). Glutathione (values at mmol/L). SOD (values at mmol/L). CAT (values at mmol/L)). Measurement time: day 0, day 6, day 11
Complete blood count (Hemoglobin (values at g/dL). Hematocrit (values at %). Red Blood Cells-Erythrocytes (values at x10^6/L), White Blood Cells-Leukocytes (values at x10^9/L), Plateles (values at x10^9/L), Lymphocytes (values at %), Monocytes (values at %), Eosinophils (values at %), Basophils (values at %), Neutrophils (values at %), Erythrocyte sedimentation (values at mm/h)). Measurement time: day 0, day 6, day 11
Blood chemistry (Albumin (values at g/L), LDH (values at U/L), ALT (values at U/L), AST (values at U/L), GGT (values at U/L), Creatinine (values at umol/L), Glucose (values at mmol/L), Bilirubin (values at mg/dl), Uric acid (values at mg/dl), Cholesterol (values at mmol/L), Triglycerides (values at mmol/L), HDL(values at mmol/L)). Measurement time: day 0, day 6, day 11